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However, emerging evidence suggests that due to biological resistance to weight loss and systemic external barriers, achieving sustainable lifestyle change can be challenging
Some individuals notice increased fatigue, muscle tightness, or reduced recovery when intake becomes lower over time
Furthermore, GLP-1R activation can prevent arterial restenosis through inhibiting VSMC proliferation and migration via stress-associated endoplasmic reticulum protein 1 (SERP1) [131]
doi: 10.2337/dc11-s231 28 GallwitzB
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