Regulators have also acknowledged reports of serious gastrointestinal complications within this drug class
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The STEP 5 data suggests that ongoing administration is necessary to maintain results, as participants who discontinued semaglutide in the STEP 1 extension study regained approximately two-thirds of the weight they had lost within one year of stopping
As of May 2026, three pivotal readouts have been reported, with additional results expected through the remainder of 2026 [1][2][8][10]
The 20mg/mL concentration handles every dose level but requires very small draws at the beginning, which makes early-phase measurements less precise
About the review The present Review summarizes evidence from major randomized trials and clinical development programs in the field, drawing on literature identified through database searches including PubMed and focusing on key advances reported through October 2025
