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When both rapid auditory processing and tonic inhibition are impaired, some studies have reported a paradoxical decrease in central gain in certain patient subgroups, particularly those without comorbid hyperacusis (Chen et al., 2021

Cunnane et al., 2020

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Glutathione's antioxidant mechanism can theoretically reduce effectiveness of pro-oxidant therapies like some cancer treatments

Similar to the protease discussed in the context of stroke, MS, and ALS, the cell-signaling analog of activate protein C, 3K3A-activated protein C, in addition to improving cerebrovascular integrity also diminished neuroinflammatory responses and slows the generation of amyloid-beta plaque buildup in AD model mice [129]

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