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Previous research has looked at single substances such as alcohol and cannabis, but a 2026 observational study in the British Medical Journal looked at multiple substances and extended its reach into opioids

The timeline for adjusting dosage can vary depending on individual factors such as BMI , overall health, and response to treatment

This info on dosages appears to come directly from Examine.coms Rhodiola page, which Layne credits at the bottom of the Instagram post

Winter SC, Szabo-Aczel S, Curry CJR, et al

2009) frameworks

Tonum cites human clinical trial data reporting about a 10.4% average weight loss over six months and notes that most of the loss was fat rather than lean mass