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GLP-1 Weight Loss Without Exercise: What to Expect GLP-1 receptor agonists such as semaglutide (Wegovy) and liraglutide (Saxenda) can produce clinically significant weight loss without structured exercise, though outcomes vary between individuals

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In this commentary, we summarize the potential effects of GLP-1RAs on CV parameters based on results from recent CV outcomes trials, and further discuss the clinical application of the agents in CV medicine