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Reconstitution math for split dosing The goal is to create a concentration that allows you to accurately measure your split dose with a standard insulin syringe

Freezing must be strictly avoided, as freezing can cause irreversible damage to the peptide structure of tirzepatide and may alter the formulation characteristics

doi: 10.1038/s41423-022-00872-3 61 KinkerGSVitielloGAFFerreiraWASChavesASCordeiro de LimaVCMedinaTDS

If a previously effective concentration suddenly yields poor results, and you can rule out other variables, peptide degradation is a likely suspect

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