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There is in fact good evidence that the number of particles matters, such that having a large number of small particles is worse than having a small number of large particles

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When approached with planned checkpoints and proportional responses, both drugs can be used safely, predictably, and effectively over the long term

TM2, in particular, adopts a conformation in the orforglipron-bound structure that would be difficult to predict computationally, highlighting the receptor's conformational flexibility and the inherent limitations of structure-based drug design for class B GPCRs

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