On average, individuals treated with retatrutide experienced a 17.5% reduction in body weight at 24 weeks and a 24.2% reduction after 48 weeks
The 12mg dose at 120 units is technically more than a 1mL syringe can hold, so you will need either a split injection or a syringe rated for at least 1.2mL
GLP-1 is a large protein hormone that cannot be absorbed through the skin
In some respects, the mechanism of GLP-1-MK-801 is similar to other therapies targeting GLP-1 receptors, in that it activates neural circuits involved in feeding, appetite, and reward
7% with placebo and 2% with dulaglutide
This extra receptor activity may help increase energy expenditure and fat metabolism, which is one reason retatrutide is being studied as a possible next step beyond dual agonist therapies