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10.1016/j.freeradbiomed.2022.06.004 28 IngoldI.BerndtC.SchmittS.DollS.PoschmannG.BudayK.et al (2018)

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And, surprisingly, the deficiency in LAC is even stronger in patients that dont respond to standard antidepressants. These results suggest that LAC levels may be used as an effective biomarkermeaning, a measurable physiological trait that can indicate the presence of disease (sometimes in combination with other diagnostic techniques)

[18] [14] However, individual patient experiences can vary, and several indirect mechanisms may contribute to sleep disruption in some people