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While the KCH criteria had excellent specificity, it was at the expense of sensitivity, yielding a limited ability to distinguish patients who would survive with conservative medical management versus those that would die without a liver transplant.52 The SOFA score, owing to its measures of physiologic parameters of multiple organ systems, was superior in discriminating patients who would benefit most from a liver transplant evaluation.52 Similar to any solid tumor transplant candidate, candidates for transplant treatment for APAP hepatotoxicity should undergo a thorough psychiatric evaluation and assessment to determine the level of social support needed
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Specifically, tenapanorto be marketed as Xphozahis intended for CKD patients on dialysis who have previously shown an inadequate response to phosphate binders or who are otherwise intolerant of such therapies
Ho et al., 1999)
