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Access remains the elephant in the room

Diabetes Obes Metab 2024

The STEP 1 trial for semaglutide 2.4mg demonstrated a mean body weight reduction of approximately 14.9% over 68 weeks in adults with obesity. The SURMOUNT-1 trial for tirzepatide showed reductions of up to 22.5% at the highest dose. These are outcomes that approach the efficacy of bariatric surgery in some patient cohorts

Pechenov, S

Those results surpassed anything previously documented with semaglutide protocols or tirzepatide protocols

This view suggests that semaglutide captures most of the available benefit from incretin-based therapy, and tirzepatides advantage comes from fine-tuning rather than fundamentally different mechanisms