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That tradeoff is unavoidable with incretin-based therapies

59 Small molecule GLP-1RA in preclinical trials MLX-7005 MLX-7005 is a highly potent, oral small-molecule GLP-1 receptor agonist (GLP-1RA) that robustly activates the GLP-1 receptor cAMP signaling pathway without measurable -arrestin recruitment

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On the contrary, a systematic review on mortality, as well as cardiovascular and kidney statuses in patients with T2DM treated with GLP-1RAs concluded that there was no increase in the incidence of severe hypoglycaemia, pancreatitis, or pancreatic cancer (222)

These receptors influence dopamine, serotonin, and stress-response pathways in the brain, which regulate mood, motivation, and emotional resilience