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In the case of an unknown theoretical background of the observed phenomena and obvious non-linear dependency, such extrapolation can lead to errors in thermodynamic quantities, as shown below

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doi: 10.1002/rmb2.12353 2 AgarwalASenguptaP

Autophagy in neurodegenerative diseases Autophagy is essential for neuronal homeostasis, especially in postmitotic neurons, which cannot dilute toxic protein aggregates through division