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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
A typical example is the hydrazone linker, which rapidly breaks under acidic conditions (pH 4.56.0) while remaining stable in plasma at pH 7.4
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Together with other clinical trial results heralding beneficial actions of drugs known to affect Nrf2 signaling, notably dimethylfumarate as an FDA-approved treatment for multiple sclerosis 83 and bardoxolone methyl for chronic kidney disease 84 , there is optimism that the overall strategies are moving forward
Jin ES, Min J, Jeon SR, Choi KH, Jeong JH: Analysis of molecular expression in adipose tissue-derived mesenchymal stem cells : prospects for use in the treatment of intervertebral disc degeneration
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