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Pairwise Euclidean distances were computed between diseases based on their Reactome pathway enrichment profiles (using normalized enrichment scores from GSEA)

Values in the table are represented as means SD determined from at least three independent experiments performed in triplicate

A practical application of the combined model would be to predict the concentration and exposure time required to cause toxicity via overwhelming GSH metabolism as a function of quinone metabolism

It is a manufacturing and safety problem

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