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Similarly, the methylated derivative of resveratrol, pterostilbene, has been observed to upregulate Nrf2, HO-1, GSH, and GPX4 while reducing ACSL4 expression and iron content in H 2 O 2 -treated COV434 and KGN cells, suggesting a potential anti-ferroptotic effect ( In addition to the Nrf2/HO-1/GPX4 pathway, other pathways have been implicated

Key Takeaways L-theanine promotes relaxation without sedation, potentially improving sleep quality, reducing stress, and enhancing focus

The creatine group increased lean body mass by an average of 1.32 kg compared to placebo

Disease Prevention Cancer Oral curcumin administration has been found to inhibit the development of chemically-induced cancer in animal models of oral (58, 59), stomach (60, 61), liver (62), and colon (63-65) cancer

Together they explain why MOTS-c is studied as a metabolic and longevity peptide rather than a quick fix