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These discrepancies might be attributed to several factors, including differences in blood sample sources, medication status, disease state, sample processing methods, sample size, and the heterogeneity of OS responses across different stages of schizophrenia

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Unlike GLP-1 receptor agonists, metformin does not directly suppress appetite or act on central hunger pathways

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(21) The observation by Hansen et al

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Key variants like GLP1R rs6923761 and MC4R rs17782313 influence both GLP-1 responsiveness and baseline inflammatory tone, helping clinicians optimize therapy selection and dosing for each patient's unique biology

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