Nutt JG, Wooten GF
Make Fibre A Priority Fibre may not be the most glamorous nutrient, but when it comes to GLP-1, its one of the most powerful, largely because of what happens when fibre reaches the gut
A small tip: using a Tonum brand logo in dark tones can help keep visual elements consistent when sharing plans or resources
For pharma companies aiming to satisfy this surging demand, the choice of delivery mechanism and delivery partner will have implications for supply chain capacity and resilience
Triple Receptor Mechanism Retatrutide is the first molecule to simultaneously engage all three receptors implicated in energy balance and body weight regulation: GLP-1 receptor: Reduces appetite, slows gastric emptying, improves glycemic control the same pathway as semaglutide (Ozempic/Wegovy) GIP receptor: Enhances insulin secretion and may contribute to fat mobilization the same dual pathway as tirzepatide (Mounjaro/Zepbound) Glucagon receptor: Increases energy expenditure, promotes hepatic fat oxidation, and drives thermogenesis a pathway unique to retatrutide among obesity therapeutics Clinical Significance In the Phase 2 trial published in the New England Journal of Medicine (2023), participants receiving the highest dose of retatrutide achieved a mean body weight reduction of 24.2% at 48 weeks with some participants losing over 30% of their body weight
CD4 + T-helper cells stimulated in response to placental ischemia mediate hypertension during pregnancy
