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They also help reduce appetite by acting on the brain

URL: org/10.101/j.diabet.2013.07.001 26

Retatrutide, with its glucagon component that increases energy expenditure, may theoretically influence energy levels differently, but clinical trial data on subjective energy has not yet been published in detail

Those numbers are sobering

It looks largely consistent with existing GLP-1 therapies, with the most common complaints being mild-to-moderate gastrointestinal side effects that typically subsided after the dose-escalation phase