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These two domains are adjacent to each other on the enzyme, and together form the active site of the GST where the redox reaction occurs

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The duration difference doesnt affect timing protocols

Accurate site documentation is not merely a coding preference it has clinical severity implications : proximal DVT (iliac, femoral, popliteal) carries higher PE risk than isolated distal/calf DVT, and may affect management decisions (anticoagulation duration, IVC filter consideration)