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But given the negative health outcomes for those living with obesity, the side effects pale in comparison, both Sattar and Cummings say

The Transcription Factor Nrf2

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A block in MMUT activity leads to accumulation of methylmalonic acid and other propionyl-CoA derived catabolites, which in turn have secondary effects on associated pathways and play a major role in the pathogenesis of MMA (3)

Data from the STEP5 Clinical Trial

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