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One amino acid swap at position 8 blocks DPP-4 cleavage

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Here we found that KL1 alone did not induce bacterial outgrowth in the liver, spleen or kidneys, indicating that it did not compromise host immune control over the infection (Extended Data Fig

1 In clinical trials, patients with higher antibody titers have been seen to have smaller reductions in A1C compared to those with low or negative titers

Key Takeaways The standard initial dose for severe deficiency is 1,000 mcg intramuscularly daily or every other day

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