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Decades of research has shown these drugs to be safe and effective treatments for type 2 diabetes

GI side effects may temporarily worsen during this escalation but usually resolve within 23 weeks

10.1016/0006-2952(92)90026-F 85 EsazadehK.Ezzati Nazhad DolatabadiJ.AndishmandH.Mohammadzadeh-AghdashH.MahmoudpourM.Naemi KermanshahiM.et al (2024)

Thus, GLP-1 analogues, such as exenatide and liraglutide, and the DPP-4 inhibitors which lower glucose levels by GLP-1 mediated effects, appear to have a very low incidence of hypoglycemia in clinical trials (Figure 13.6)

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