Clinical Update 7/22/2024 Ocuvite for Macular Degeneration
Functioning as a free radical scavenger, it plays a pivotal role in safeguarding our DNA, cellular lipids, and proteins from the detrimental effects of oxidative stress, earning it the esteemed title of "master antioxidant." Glutathione stands as a crucial and highly efficient endogenous antioxidant within the body
At the molecular level, 5-amino-1MQ functions as a competitive inhibitor of NNMT, demonstrating remarkable potency with an IC of 1.2 0.1 M under standard assay conditions (50 M SAM, 100 M nicotinic acid). This represents a dramatic 10-fold improvement over the parent compound 1-methylquinolinium, achieved through strategic amino group substitution that enhances binding affinity to the NNMT active site. The compound's mechanism centers on preventing the methylation of nicotinamide to 1-methylnicotinamide (1-MNA), thereby preserving nicotinamide for recycling back to NAD+ through the salvage pathway. This intervention effectively blocks what researchers have termed the "NNMT metabolic drain" a process that simultaneously depletes NAD+ precursors and consumes cellular methylation capacity
The Nrf2/Keap1/ARE pathway, along with other signaling pathways such as Sirt1/p66Shc and NLRP3/caspase-1/GSDMD, are involved in mediating oxidative stress and inflammation in doxorubicin-induced cardiomyopathy [69]
M., Moreno, A
Spend Time in Nature: Even a short walk outside can help reduce stress levels
