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10.1038/s41586-019-1705-2 8 Bosello-TravainV.ConradM.CozzaG.NegroA.QuartesanS.RossettoM.et al (2013)

Various resistant analogs, such as exendin 4 (exenatide, Amylin), and albumin-based forms, such as liraglutide (NovoNordisk), may improve glycemic control and reduce body weight.93 Finally, among bariatric surgery techniques, intestinal bypass surgery is successful in reducing food intake and in causing weight loss because of enhanced secretion of satiety signals as GLP-1 and PYY.94 Gut hormones and liver disease NAFLD (non-alcoholic fatty liver disease) represents a disease spectrum ranging from simple steatosis to steato-hepatitis and fibrosis.95 The prevalence of NAFLD is about 1733% in the Western world countries so that it shows to be the most prevalent liver disease, more than chronic hepatitis C virus or alcoholic liver disease

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In response, the body ramps up production of certain chemicals like opioids, to counteract this blockade

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