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Importantly, Zepbound carries a boxed warning regarding thyroid C-cell tumors observed in rodent studies and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

It makes it harder for endurance athletes to know when they are really thirsty and, in turn, can result in dehydration

Zepbound, with its dual-agonist approach, has showcased a promising edge in efficacy, potentially driving a paradigm shift in obesity treatment, while Wegovy, though slightly trailing, remains a solid contender, especially with potential future combinations enhancing its performance

Unlike exogenous GH administration, GHRH analogs preserve the physiologic feedback loop, resulting in more natural GH pulsatility without the risks associated with supraphysiological GH levels [7]

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Gastric Emptying and Satiety Effects of Tirzepatide