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Effects of liraglutide on clinical stability among patients with advanced heart failure and reduced ejection fraction: A randomized clinical trial

Some patients maintain clinically meaningful weight loss at semaglutide 1.0 mg or tirzepatide 5 mg rather than the labeled maximum

Current guidance recommends stopping GLP-1 medications before conception and avoiding use during pregnancy due to insufficient safety data

This persistence of symptoms after stopping the medication particularly strengthens causation arguments in litigation, as it demonstrates lasting injury rather than temporary side effects

But prior to teaming up with Samols he had no means to prove his hypothesis (D'Alessio, Marks)

For other potential indications such as substance use disorders or depression, more randomized controlled trials in humans are still needed