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Most gastrointestinal symptoms diminish over several weeks as physiological adaptation occurs, particularly after the initial dose escalation period
(INS = insulin, GCG = glucagon, SST = somatostatin)
After two or more weeks without administration, restarting at the full maintenance dose risks severe gastrointestinal distress because receptor adaptation has partially reversed
Dose optimization One of the most overlooked cost reduction strategies is dose optimization
& Habener, J
IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045
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