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Wheeler CR, Salzman JA, Elsayed NM et al

PPARalpha and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia

Interestingly, this mechanism may be used to sensitize liver cancer cells to the drug sorafenib, and the mechanism is based precisely on the impairment of the ability to defend against drug-related oxidative stress

TNF- has also been shown to decrease the expression of genes involved in insulin signalling [23]

This depletion leads to the accumulation of lipid ROS through Fe 2+ -catalyzed peroxidation reactions (29)

These factors can affect how research materials are stored and reviewed over time