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There are many examples of how hepatocytes organize metabolic processes in space and time to prevent the accumulation of these toxic VPA metabolites or reduce their level in organs and tissues in which biological processes that are most sensitive to toxic VPA metabolites occur [13] (Figure 4)

Statistical significance was analyzed by ordinary two-way ANOVA followed by dks multiple comparisons in a , b

Where indicated, cells were treated with 2-h pulses of 1 M epirubicin, 5 M 5FU, twice a week or irradiated with 2 Gy (once a week using an Xstrahl CIX2 or RPS CellRad RSM-009 irradiators)

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