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The sudden shift in eating patternsboth reduced portion sizes and changed food preferencesdisrupts the balance of bacteria that normally regulate digestion

Furthermore, studies such as the STEP-HFpEF trial with GLP-1 receptor agonists have shown optimized exercise capacity and reduced heart failure symptoms in patients

Diab Ther

Indication-specific advantages: Glucagon co-agonists such as survodutide, mazdutide, and retatrutide may have superior hepatic effects in MASH and MASLD because glucagon acts directly on liver lipid metabolism