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Despite the observations of an effect of GH and IGF-I on protein synthesis, the fact remains that gains in muscle mass are not observed in healthy subjects after long-term GH administration so any benefits are unlikely to be due to muscle mass gains

10.1016/j.jmii.2019.10.006 125 XuS.GaoY.ZhangQ.WeiS.ChenZ.DaiX.et al (2016)