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Its mechanism does not involve hormonal disruption, and clinical trials showed no sex-specific adverse effects

MHRA Updated Semaglutide Guidance Including NAION Warning (GOV.UK, February 2026) 3

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During the first week, the HJEs (passage 0) are incubated in the Intesticult Organoid Growth Medium (Stem Cell) with a ROCK pathway inhibitor (Y-27632, Biotechne, 10 M) in a 37 C, 5% CO 2 incubator