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Activation of the PGC-1 pathway, involved in mitochondrial biogenesis and oxidative stress regulation, has shown neuroprotective effects in PD models (Mesarosova et al

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Students in the SAD group reported less socio-familiar support ( H 3 = 23.44, p = 0.0001

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Notably, bile acid signaling pathways can also contribute to OA pathology, as indicated by the alleviation of murine OA after suppression of farnesoid X receptor-the receptor for the bile acid glycoursodeoxycholic acid (GUDCA), which upregulates intestinal glucagon-like peptide-1 secretion (Yang et al., 2025)