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Achieving greater systemic exposure with a lower administered dose can reduce pill burden and support sustained supplementation, thereby enhancing the feasibility of long-term use. Source: Antioxidants

One of those circuits handles detoxification

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Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells (Stockwell, 2022)

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