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According to the NCCD, the key determinants that define apoptosis as an RCD are its initiation by caspase-8 and caspase-9 and cell death execution by caspase-3, caspase-6, and caspase-7, which occur at the terminal stage when the cells are already committed to die [6, 73]

Nguyen HL, Linh HQ, Krupa P et al (2022) Amyloid dodecamer disrupts the neuronal membrane more strongly than the mature fibril: understanding the role of oligomers in neurotoxicity

doi: 10.1016/j.jep.2022.115031 50

If you are also iron deficient, both contribute to the same picture, which is why testing them together makes sense

Disruption of the microsomal glutathione S-transferase-like gene reduces life span of Drosophila melanogaster

The combination of graphene, AuNPs, and peptide bioreceptors resulted in robust signal enhancement, making this biosensor a promising tool for fast and reliable point-of-care diagnostics in clinical settings