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Relative contraindications (metformin use, proton pump inhibitors) require monitoring

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In addition to being a therapeutic target, oxidative stress has been shown to decrease the GSH:GSSG ratio which has proven useful as a clinically accessible, pharmacodynamic biomarker of immune redox tone for conditions such as malignancy (Zitka et al., 2012)

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Trial averages also hide a wide individual spread in outcomes

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As ITCA 650 contributed minimally to the pooled estimate, its potential bias did not materially affect the overall assessment

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