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In GLP-1s, both adverse effects and side effects primarily stem from their mechanisms of action, impacting multiple physiological systems, including the GI tract, pancreas, and central nervous system

The mechanisms of action include: Enhancement of glucose-dependent insulin secretion Suppression of glucagon secretion Delay in gastric emptying Increased satiety and appetite suppression These effects collectively lead to improved glycemic control and significant weight reduction

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A comprehensive review by Vollbracht & Kraft (2021) assessed 9 clinical studies involving 720 participants suffering from fatigue related to various viral infections, including Herpes Zoster

In the absence of evidence, clinicians and patients should exercise considerable caution

This story is updated with new information.