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Hand Hygiene: Before handling the syringe, needle, or vial, thoroughly wash your hands with soap and water, or use an alcohol-based hand sanitiser to reduce the risk of introducing contaminants

What to track Body weight is the obvious metric, but it is not the most informative during the first 4 to 6 weeks

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Signal changes were evaluated relative to the Day 1 baseline, as it represents the highest initial signal prior to fasting

Of these trials, four compared DPP-4 inhibitors against placebo (SAVOR-TIMI 53, EXAMINE, TECOS, CARMELINA), eight compared GLP-1RA against placebo (ELIXA, LEADER, SUSTAIN-6, EXSCEL, HARMONY, REWIND, PIONEER 6, AMPLITUTE-O) and eleven compared SGLT-2 inhibitors against placebo (EMPA-REG, CANVAS, DECLARE, CREDENCE, DAPA-HF, DAPA CKD, VERTIS-CV, EMPEROR-R, SCORED, SOLOIST-WHF, EMPEROR-P)

This included examining national and international safety reporting guidance, reviewing serious adverse event reporting procedures from other pharmacological and non-pharmacological trials, a review of the literature and collaboration between the ACTION study team and Data Safety Monitoring Committee