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PLoS ONE 13:e201369 Hu Q, Zhang Y, Lou H, Ou Z, Liu J, Duan W, Wang H, Ge Y, Min J, Wang F, Ju Z (2021) Gpx4 and vitamin e cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis

If tolerated, the dose is increased over time until the maximum is reached

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For example, after cell stress, p53 interacts with the proapoptotic protein Bak, which promotes the oligomerization of Bak and the release of cytochrome c from mitochondria to induce apoptosis