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It contains semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist

Reference: Maher P (2005)

Semaglutide was notably associated with high risks of ischemic optic neuropathy and diabetic retinopathy

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First Human Niagen Study That Demonstrates Effectiveness: A study published in Nature Communications in 2016 reports that single oral doses of 100mg, 300mg, and 1,000mg of Niagen can safely elevate NAD+ levels. Researchers investigated the effects of NR supplementation in 12 healthy men and women, establishing both its safety and efficacy as an NAD+ precursor in humans

A growing plaque may restrict blood flow and cause symptoms of ischemia (reduced blood flow)