The growth signal is therefore indirect and paracrine : activating those receptors releases IGF-1, IGF-2, keratinocyte growth factor and nitric oxide , and those mediators drive crypt-cell proliferation, increased villus height, deeper crypts and increased intestinal and portal blood flow [1] [5]
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These effects, when they occur, are usually short-lived
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Mn2 + is also an excellent contrast agent for T1-weighted MRI