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Several of these legal challenges have resulted in temporary restraining orders or preliminary injunctions that have allowed compounding to continue in certain circumstances even after FDA actions that would otherwise have curtailed it
and (5) formation of stable conjugates to prevent reactive aldehydes and lipid peroxidation (non-enzymatic detoxification of reactive aldehydes) from occurring
A Phase IIb study comparing cotadutide with the GLP-1R mono-agonist liraglutide showed that, after 54 weeks, cotadutide produced similar HbA 1c reductions (cotadutide vs liraglutide: 13.0 mmol/mol vs 12.8 mmol/mol [1.19% vs 1.17%]) but greater bodyweight reductions than liraglutide (5.02% vs 3.33%) [6]
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