Since ALC is transferred through intestinal serous membranes better than non-acetylated L-carnitine, the intracellular acetylation of carnitine may facilitate its diffusion across the serosal membrane [56]
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Moreover, IL-1 has been shown to trigger hepatic Kupffer cells and hepatocyte injury in MASLD models, suggesting its possible role in early disease stages [252]
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Variants in SLC19A1 have been associated with impaired MTX transport and resistance, while SLCO1B1 low-activity haplotypes have been linked to delayed MTX clearance and increased toxicity risk (Wang et al
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