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It works by mimicking the hormone GLP-1 (glucagon-like peptide-1), which increases insulin secretion, decreases appetite, and slows gastric emptying

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It promotes greater energy availability by reducing the feeling of fatigue

They both likely accomplish this by improving cardiovascular disease risk factors such as improving blood sugar control, improving blood pressure, promoting weight less, reducing inflammation, and improving blood vessel function. The researchers reviewed 601 published trials of older people to investigate whether the efficacy of three medications DPP-4 inhibitors, SGLT2 inhibitors, and GLP-1 agonists was affected by the age or sex of people with type 2 diabetes

Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity

April 08, 2026 The onslaught of media coverage about blockbuster weight-loss drugs, such as Ozempic and Zepbound, may make it seem as though they work magic