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Optogenetic stimulation of PVH-projecting GABA LH neurons increases inhibitory post-synaptic current (IPSC) in PVH neurons, leading to increased feeding, while disruption of GABA receptors in the PVH reduced feeding [89]

The article describes semaglutide as creating a six to twelve month window to establish new eating patterns, reduce portion sizes, and build consistent physical activity while appetite is suppressed

Gut Hormones : While saffrons direct effects on GLP-1 are not well-documented, its impact on gut health and reduced inflammation may support better incretin hormone dynamics

Regarding tolerability, evidence indicates that GLP-1RAs are safe for non-diabetic obese patients

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