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In November 1920 Banting and Best began the process of extracting insulin from islet cells taken from the pancreases of cows and pigs (Hall Jan 2022)

Hernandez AF, Green JB, Janmohamed S et al (2018) Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (harmony outcomes): a double-blind, randomised placebo-controlled trial

Retatrutide has not yet been studied in a dedicated cardiovascular outcome trial

Regular intake of probiotics has been associated with improved digestion, reduced inflammation, and a strengthened immune system

In the 2021 trial referenced above, participants receiving tirzepatide also had greater reductions in body weight than those on semaglutide

The three major hurdles that prevent faster and vast progress such as less sustainable behavior change, medication side effects, and medication cost