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In the original 2017 mouse study, FOXO4-DRI was reported as well-tolerated in vivo at the dosing used

When youre knocking back more than what your liver can handle within an hour, that excess ends up coursing through your bloodstream, leading to intoxication

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[5] Avoid B12 shots if: You have kidney or liver disease

Impaired GSH function is associated not only with neurodegenerative diseases, like Alzheimer's disease, but also with broader issues related to brain metabolism and oxidative stress (Iskusnykh et al., 2022)

And the superstar, vitamin B12, adds that extra kick to keep your energy levels high