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Sample sizes were small and the study has never been replicated at scale, so take it as suggestive, not definitive

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Senolytic drugs: from discovery to translation Kirkland JL, Tchkonia T Journal of Internal Medicine (2020) This comprehensive review from the Mayo Clinic's leading senescence researchers places FOXO4-DRI within the broader context of senolytic drug development and clinical translation

The only other human study, from 2015, was abandoned by 2016 the researchers had cancelled submission of the results [15]