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A phase 2 study published in the New England Journal of Medicine described retatrutide as a triple-hormone receptor agonist for obesity

35 Without this stimulus, especially during a calorie deficit potentially exacerbated by GLP-1 effects, the body may be less efficient at utilizing dietary protein for muscle maintenance, leading to greater lean mass loss

In particular they wanted to evaluate the biological activity of naturally occurring GLP-1 extracted from the mucous membrane of both human and pig intestines as well as commercially sourced synthetic replicas of GLP-1

Retatrutides effectiveness in both adipose tissue reduction and glycemic control suggests it could be a game-changing therapy for type 2 diabetes and obesity management (McPherson et al., 2023)

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